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| Registros recuperados: 18 | |
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| Flores-Lopes,Fábio; Malabarba,Luiz R.; Pereira,Edson H.L.; Silva,José F. Pezzi da. |
| Little information is available about natural populations of fishes exposed to polluted waters in Brazil. Contaminants may be lethal or predispose fishes to sickness, being the analysis of aquatic organisms a good indicator of environmental quality. The violinha, Rineloricaria strigilata (Hensel, 1868), is a common loricariid catfish in the Guaíba lake basin, Rio Grande do Sul, Brazil, and has been selected as a bioindicator for being resident, occurring in more than 50% of the samples, and by showing externally detectable neoplasies. These are characterized by its dark pigmentation, bony plates hypertrophy, and hypertrophy and irregular arrangement of the odontodes. Histology showed hypertrophied epitelial tissues, with an increased number of secretory... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Rineloricaria strigilata; Bioindicator; Neoplasm. |
| Ano: 2001 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-81752001000300006 |
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| Silva,I.L.D.; Dias,A.P.M.; Bertagnolli,A.C.; Cassali,G.D.; Ferreira,E.. |
| Biomolecular evidence has shown that ductal carcinoma in situ(DCIS) may develop into invasive carcinoma of the canine mammary gland, and mutations in proto-oncogenes HER2 and EGFR; two members of the family of epidermal growth factor receptors, may be involved in this process. The purpose of this study was the characterization of the immunohistochemical expression of the EGFR and HER2 proteins in the process of neoplastic transformation, supposedly present in ductal carcinomas in situin canine mammary glands. Fifteen cases of DCIS were evaluated, with a higher expression of HER2 and EGFR being observed in low-grade carcinomas when compared with high-grade neoplasms, and with a high positive statistical correlation in the latter. Results suggest that... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Dog; Neoplasm; Immunohistochemistry; EGFR; CerbB2. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352014000300763 |
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| Souza,P.C.; Ocarino,N.M.; Tavares,W.L.F.; Boeloni,J.N.; Cassali,G.D.; Serakides,R.. |
| Mitotic index, nuclear diameter, number of nucleolar organizing regions, and Ki-67 expression, in hair follicle tumors of 82 dogs were evaluated. Tissue specimens were used to prepare sections for histological staining for number of nucleolar organizing region and immunohistochemical staining for Ki-67. Tumors were classified as trichoblastoma (n=32), benign trichoepithelioma (n=30), pilomatricoma (n=7), malignant trichoepithelioma (n=6), infundibular keratinizing acanthoma (n=5), and tricholemmoma (n=2). Head, dorsum, and limbs were the most affected sites. Malignant trichoepithelioma presented significantly higher mitotic index, number of nucleolar organizing regions and Ki-67 expression. Regarding benign neoplasms, trichoblastoma presented significantly... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Dog; Neoplasm; AgNOR; Hair follicle; Ki-67. |
| Ano: 2008 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352008000500006 |
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| Argenta,Fernando Froner; Pereira,Paula Reis; Bertolini,Marianna; Fratini,Letícia Mendes; Saccaro,Renata de Oliveira; Sonne,Luciana; Driemeier,David; Pavarini,Saulo Petinatti. |
| ABSTRACT: A carcinoid is a rare neoplasm derived from neuroendocrine cells that may arise in the hepatobiliary system. This report described two cases of carcinoid of the gallbladder in dogs, with emphasis on the clinical, pathological and immunohistochemical aspects. Case 1 was a 10-year-old female Shih Tzu, with a history of prostration and occasional episodes of diarrhea and vomiting. Case 2 was a 10-year-old male Cocker Spaniel, with a history of diarrhea and abdominal pain. Abdominal ultrasonography suggested a neoplasm of the gallbladder in both cases. The dogs underwent cholecystectomy, and 10% formalin-fixed samples were sent for pathological examination. Histologically, a neoplastic proliferation of neuroendocrine cells was observed in the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Canine; Neoplasm; Neuroendocrine carcinoma; Immunohistochemistry. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782020000200551 |
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| Souza,D.M.B.; Barros,M.G.O.; Silva,J.S.C.; Silva,M.B.; Coleto,Z.F.; Jimenez,G.C.; Adrião,M.; Wischral,A.. |
| Fifteen female canines with mammary tumors and 6 normal females were used to study mutations in exons 4 to 8 of the p53 gene. DNA samples from the tumors, respective adjacent normal mammary tissue and mammary glands from healthy animals were sequenced and analyzed for the presence of mutations. Mutations were found in 71.8% of the samples and the most frequent were missense mutations. The most attacked exons in the mammary tumor were 5, 7 and 8, with 23.4, 31.6 and 23.4% mutations, respectively. Canine mammary tumors are related to mutations in gene p53 and mutations mostly occur in the region of the protein that is linked to the DNA in the cell nucleus, which can change the functionality of the cell and propitiate tumor growth. Despite being... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Bitch; DNA; Mamma; Molecular biology; Neoplasm; PCR. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352012000200013 |
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| Cassali,G.D.; Salvador,A.; Freitas,C.; Dutra,A.P.; Schmitt,F.C.. |
| Flow cytometric analysis of DNA content was performed on 28 samples of canine mammary tumors. Nine of them were benign and 19 were malignant. All benign tumors and 11 malignant tumors (57.9%) were diploid (P<0.05). Form the aneuploid tumors, five (26.3%) were hyperdiploid, one (5.3%) hypodiploid, one (5.3%) near triploid and one (5.3%) multiploid. The analysis of the expression of the markers PR and CD31 revealed a significant difference between diploid and aneuploid tumors (P<0.05). The immunoreactivity of PR was higher in diploid tumors, while the immunoreactivity of CD31 was stronger in aneuploid tumors. No difference between the markers MIB-1, c-erbB2, p53 and Cyclin D1 was observed (P>0.05). Using the flow cytometry analysis and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Dog; Breast cancer; Neoplasm; DNA flow cytometry; Immunohistochemistry. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352007000500011 |
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| Dong,Wenzhu; Chen,Hangping; Wang,Lu; Cao,Xiaoqian; Bu,Xiawei; Peng,Yan; Dong,Aiqing; Ying,Mengjiang; Chen,Xu; Zhang,Xin; Yao,Li. |
| Given their relationship with metabolic syndrome and systematic inflammatory diseases, the pathogenesis of hypertension, hyperglycemia, and hyperlipidemia is closely related. To explore the common genes among these three conditions, spontaneous hypertensive rats (SHR), spontaneous diabetic Goto-Kakizaki rats (GK) and hyperlipidemia rats (HMR) were reared for experiments. Gene array was used to identify the genes of SHR, GK and HMR compared with normal Wistar rats using TBtools software. First, real-time PCR was applied to verify these genes, and Cytoscape software was used to construct networks based on the National Center for Biotechnology Information (NCBI) database. Second, Kyoto Encyclopedia of Genes and Genomes (KEGG) database analysis was performed... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hypertension; Diabetes; Hyperlipidemia; Genes; Microarray; Neoplasm. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100566 |
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| Chaves,R.O.; Bazzi,T.; Copat,B.; Feranti,J.P.S.; Müller,D.C.M.; Corrêa,L.F.D.; Fighera,R.A.; Mazzanti,A.. |
| ABSTRACT This paper reports a case of a rare variant of the cervical spinal cord astrocytoma diagnosed in a dog with progressive neurological signs, initially asymmetrical, not ambulatory tetraparesis, segmental reflexes and normal muscle tone in all four limbs and absence of pain upon palpation of the cervical spine. Myelography revealed attenuation of the ventral and dorsal contrast line in the third region of the fifth cervical vertebra. At necropsy intramedullary cylindrical mass that stretched from the third to the sixth cervical vertebra, which replaced all the gray matter of the spinal cord was observed. In the histological study, there was the replacement of the substance by neoplastic cells mantle arranged loosely. The cells were large and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Canine; Neoplasm; Glioma; Spinal cord. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352016000400901 |
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| Campos,C.B.; Gamba,C.O.; Damasceno,K.A.; Lavalle,G.E.; Cassali,G.D.. |
| ABSTRACT The aim of this report is to describe the first histopathological, immunohistochemical, and clinical characteristics of a feline glycogen-rich clear cell carcinoma (GRCCC). A Persian queen was admitted with mammary gland tumors and underwent radical unilateral mastectomy. Overall survival was considered 33 days and death was due to clinical evolution of the disease. Microscopic evaluation demonstrated epithelial cells arranged in a predominantly solid pattern, tumor cells presented an ample, granular, and foamy clear cytoplasm, and moderate cellular pleomorfism. The presence of cytoplasmatic glycogen was confirmed through diastase digestion followed by PAS staining. Histopathological and histochemical findings lead to the diagnosis of GRCCC with... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Feline; Mammary gland; Neoplasm; Glycogen-rich clear cell carcinoma. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352016000501117 |
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| Brito,Marilene de Farias; França,Ticiana Nascimento; Jabour,Flávia Figueiraujo; Seixas,Josilene Nascimento; Andrade,Gisele Braziliano; Oliveira,Laura Iglesias; Peixoto,Paulo Vargas. |
| A malignant dendritic melanoma of the oral cavity with metastases widely spread in a cow is described. The clinicopathological manifestations, developed during a two-year period, was characterized by the difficulty in mastication and swallowing, progressive weight loss, weakness and profuse sialorrhea. At the necropsy, an ulcerated black mass was found at the left jaw projecting into the oral cavity. The tumor reached the chin, inferior lip and tongue. Metastases were detected within the tongue, parotid gland, lymph nodes, trachea, thyroid, pleura, lungs, heart, peritoneum, omentum, and serosal membranes of the forestomach and abomasum, liver, and intima of some hepatic vessels, mammary gland, and muscles and fasciae of the left hind leg. No reference to... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Oral dendritic melanoma; Cattle; Pathology; Neoplasm. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782009000400045 |
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| Horta,R.S.; Lavalle,G.E.; Costa,M.P.; Moura,L.L.; Marcinowska,A.; Araújo,R.B.. |
| ABSTRACT In spite of the many available protocols, the use of chemotherapy for the management of canine mast cell tumours (MCT) remains empirical, and there is lack of criteria for the choice of protocol and definition of patients who may benefit from treatment. The objective of this study was to evaluate the outcome of dogs with MCT after adjuvant chemotherapy according to the risk of recurrence or metastasis proposed on the literature. This prospective study included 89 followed up dogs with prognosis assesment including clinical, histological, immunohistochemical and genetic features of canine MCT. Patients were grouped according to risk of recurrence and metastasis and recommended treatment with lomustine followed by chlorambucil if considered at... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Dog; Neoplasm; Mast cells; Ki-67; C-kit. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352017000601426 |
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| Conceição,L.G.; Camargo,L.P.; Costa,P.R.S.; Kuwabara,D.A.; Fonterrada,C.O.. |
| Três casos de carcinoma multicêntrico in situ de células escamosas (doença de Bowen) são descritos na espécie felina. As neoplasias ocorreram em gatos idosos e acometeram a região pré-auricular, cervical, abdominal e flancos. Um gato apresentou lesão única e os demais apresentaram lesões multifocais, que se caracterizaram por placas que variavam de hiperceratóticas a verruco-crostosas e eram hiperpigmentadas. Algumas eram ulceradas, com fissuras que sangravam facilmente. Histologicamente, as células neoplásicas encontravam-se confinadas à epiderme e aos folículos pilosos, sem o envolvimento da membrana basal. Em um dos casos houve melhora significativa das lesões após terapia oral com acitretina. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cat; Neoplasm; Multicentric squamous cell; Bowens disease; Dermatosis. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352007000300039 |
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| DELOU,JOÃO M.A.; BIASOLI,DEBORAH; BORGES,HELENA L.. |
| ABSTRACT Physiological processes, as autophagy, proliferation and apoptosis are affected during carcinogenesis. Restoring cellular sensitivity to apoptotic stimuli, such as the antineoplastic cocktails, has been explored as a strategy to eliminate cancer cells. Autophagy, a physiological process of recycling organelles and macromolecules can be deviated from homeostasis to support cancer cells survival, proliferation, escape from apoptosis, and therapy resistance. The relationship between autophagy and apoptosis is complex and many stimuli can induce both processes. Most chemotherapeutic agents induce autophagy and it is not clear whether and how this chemotherapy-induced autophagy might contribute to resistance to apoptosis. Here, we review current... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Retinoblastoma; Neoplasm; Autophagy; Cell death; Antineoplastic agents. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000602257 |
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| Blume,Guilherme Reis; Oliveira,Ayisa Rodrigues de; Mattioli,Mariana Portugal; Oliveira,Letícia Batelli de; Reis Junior,Janildo Ludolf; Sant'Ana,Fabiano José Ferreira de. |
| Chondrosarcoma is a malignant mesenchymal tumor in which the neoplastic cells produce cartilaginous matrix and is uncommonly described in birds. This report describes the clinical and pathological findings of one case of chondrosarcoma in a blue-fronted parrot (Amazona aestiva). Macroscopically a 3.6x3.5x1.8cm, nodular, ulcerated, and firm mass was identified in the dorsal synsacrum. Microscopically, the mass was composed of a monomorphic proliferation of pleomorphic spindle chondrocytes with abundant cartilaginous matrix, consistent with chondrosarcoma |
| Tipo: Info:eu-repo/semantics/report |
Palavras-chave: Oncology; Psittacine; Neoplasm. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782015000300525 |
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| Registros recuperados: 18 | |
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